In Vitro Inhalation Bioaccessibility of Phthalate Esters and Alternative Plasticizers Present in Indoor Dust Using Artificial Lung Fluids
Autor: | Anna Palm-Cousins, Chris D. Collins, Katerina Kademoglou, Juan Antonio Padilla-Sánchez, Cynthia A. de Wit, Jörgen Magnér, Georgios Giovanoulis |
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Rok vydání: | 2018 |
Předmět: |
Chromatography
010504 meteorology & atmospheric sciences Ecology Inhalation Lung deposition Chemistry Health Toxicology and Mutagenesis Plasticizer Phthalate 010501 environmental sciences complex mixtures 01 natural sciences Pollution Artificial lung In vitro 3. Good health chemistry.chemical_compound Adverse health effect Environmental Chemistry Waste Management and Disposal 0105 earth and related environmental sciences Water Science and Technology |
Zdroj: | Environmental Science & Technology Letters. 5:329-334 |
ISSN: | 2328-8930 |
Popis: | Phthalate esters (PEs) are used as plasticizers in consumer products. Their low migration stability has resulted in the classification of PEs as major indoor contaminants. Because of PE’s ubiquity and adverse health effects on humans and especially children, non-phthalate alternative plasticizers have been introduced into the market. This is the first study of in vitro inhalation bioaccessibility of PEs (e.g., DMP, DEP, and DEHP) and alternative plasticizers (e.g., DEHT and DINCH) via indoor dust to assess inhalation as an alternative route of exposure. Two artificial lung fluids were used, mimicking two distinctively different pulmonary environments: (1) artificial lysosomal fluid (ALF, pH 4.5) representing the intracellular acidic lung fluid inhaled particle contact after phagocytosis by alveolar macrophages and (2) Gamble’s solution (pH 7.4), the extracellular healthy fluid for deep lung deposition of dust. DMP and DEP were highly bioaccessible (>75%), whereas highly hydrophobic compounds such as DEHP,... |
Databáze: | OpenAIRE |
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