Impact of fluconazole prophylaxis on fungal colonization and infection rates in neutropenic patients
| Autor: | Michel Laverdiere, Eric J. Bow, Coleman Rotstein, Robin S. Roberts, Narguess Moghaddam, Stratis Ioannou, Danielle Carr |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pharmacology
Microbiology (medical) medicine.medical_specialty Leukopenia biology Candida glabrata Opportunistic infection Neutropenia biology.organism_classification medicine.disease Gastroenterology Infectious Diseases Internal medicine Immunology Chemoprophylaxis medicine Pharmacology (medical) Colonization medicine.symptom Candida albicans Fluconazole medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 46:1001-1008 |
| ISSN: | 1460-2091 |
| DOI: | 10.1093/jac/46.6.1001 |
| Popis: | Fungal colonization profiles from four different anatomical sites were evaluated in 266 neutropenic cancer patients receiving intensive cytotoxic therapy for acute leukaemia or for autologous marrow transplantation. At the beginning of chemotherapy patients were allocated randomly to receive oral fluconazole 400 mg daily or an identical placebo until prophylaxis failure or marrow recovery. Candida albicans colonization was reduced from 30 to 10% in the fluconazole recipients while it increased from 32 to 57% in the placebo patients (P 0.25 was 76% sensitive but only 69% specific for invasive fungal infection. However, a colonization index < or =0.25 at baseline had a negative predictive value of 88% for development of invasive fungal infection. Fluconazole prophylaxis decreased colonization by fungi and subsequent invasive fungal infections in neutropenic cancer patients. |
| Databáze: | OpenAIRE |
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