Injection with long chain triglyceride or long chain triglyceride/medium chain triglyceride propofol: Which is less painful?
| Autor: | Raman D. Damor, Kalpita Shringarpure, Pankajkumar B Parmar, Jyotsna F Maliwad, Jaydev K Dave |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Mild pain
business.industry Incidence (epidemiology) Anaesthetic Agent 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Pharmacokinetics 030220 oncology & carcinogenesis Anesthesia medicine General anaesthesia Long chain triglyceride Medium-chain triglyceride Propofol business medicine.drug |
| Zdroj: | Indian Journal of Clinical Anaesthesia. 7:54-58 |
| ISSN: | 2394-4994 2394-4781 |
| DOI: | 10.18231/j.ijca.2020.010 |
| Popis: | Introduction: Long chain triglyceride/Medium chain triglyceride (LCT/MCT) Propofol 1% suspension is a new formulation having 10% fat emulsion consisting of long chain triglycerides (LCT) and medium-chain triglycerides (MCT). The pharmacokinetics and efficacy are similar to the standard Propofol LCT. Objective: To compare incidence, intensity of pain on injection and hemodynamic stability with both 1% Propofol -LCT and 1% Propofol-LCT/MCT in patients undergoing surgery with general anaesthesia. Materials and Methods: This was a comparative study conducted in Shri M.P. Shah Medical College and Guru Gobind Hospital, Jamnagar. After due ethical clearances, 60 patients were divided into L group and L/M group by using random number table after taking written informed consent. The L-Group received 1% propofol-LCT while the L/M group received 1% propofol-LCT/MCT. After induction, pain was assessed using Verbal Rating Score for incidence and intensity of pain. Results: In L-group, 29 (96.67%) patients complained of pain, while in L/M-group 24 (80%) patients perceived pain. Ten (33.3%) patients in L group and 18 (60%) in L/M group had none to mild pain, but moderate to severe pain was perceived by 20 (66.67%) patients in L group compare d to 12(40%) in L/M group. The incidence of pain and intensity of pain on injection was greater in group L (p=0.04 and 0.03 respectively). Conclusions: Propofol-LCT/MCT may be considered in place of propofol-LCT as an anaesthetic agent since it reduces pain of injection. Keywords: Propofol LCT/MCT, General anaesthesia, Verbal Rating Score, Pain intensity. |
| Databáze: | OpenAIRE |
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