Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury
| Autor: | Ned D. Heindel, Jeffrey D. Laskin, Cynthia Fianu‐Velgus, Erik Aponte, Sherri C. Young, Irene M. Wohlman, Christophe Guillon, Laurie B. Joseph, Diane E. Heck, Carl Jeffrey Lacey, Jaya Saxena |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Molecular pathology medicine.drug_class General Neuroscience Sulfur mustard Prodrug Pharmacology General Biochemistry Genetics and Molecular Biology Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Enzyme History and Philosophy of Science Downregulation and upregulation chemistry Drug development 030220 oncology & carcinogenesis medicine Receptor |
| Zdroj: | Annals of the New York Academy of Sciences. 1378:174-179 |
| ISSN: | 0077-8923 |
| DOI: | 10.1111/nyas.13177 |
| Popis: | The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years. |
| Databáze: | OpenAIRE |
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