Veränderungen des zerebralen Metabolismus und des zerebralen Blutflusses unter Halothan und Isofluran in steigenden Konzentrationen

Autor:	T. Brüssel, H. Van Aken, W. Fitch
Rok vydání:	1992
Předmět:	Mean arterial pressure Chemistry Hemodynamics General Medicine Critical Care and Intensive Care Medicine Anesthesiology and Pain Medicine Blood pressure Isoflurane Cerebral blood flow Anesthesia Circulatory system Emergency Medicine medicine Halothane Cerebral perfusion pressure medicine.drug
Zdroj:	AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie. 27:414-420
ISSN:	1439-1074 0939-2661
Popis:	The results of two studies on the effects of halothane and isoflurane in increasing end-tidal concentrations (0.25; 0.5; 1.0vol%) on the cerebral metabolic rate for oxygen and the cerebral blood flow are compared. Both studies were performed on baboons using the same experimental model. Cerebral blood flow was determined from a washout curve after the intracarotid injection of 133xenon. Halothane and isoflurane led to a dose-dependent decrease of the cerebral metabolic rate for oxygen. Increasing concentrations of halothane caused a decrease of cerebral oxygen consumption from 3.4 +/- 0.8 (baseline) to 2.9 +/- 0.8 (0.25vol%), 2.7 +/- 0.7 (0.5vol%) and 2.4 +/- 0.4 mlO2 100 g-1min-1 at 1.0vol%. The administration of isoflurane reduced the cerebral oxygen consumption significantly from baseline 3.7 +/- 1.0 to 2.9 +/- 0.9 at 0.25vol%, 2.6 +/- 0.6 at 0.5vol% and 1.8 +/- 0.8 mlO2 100 g-1min-1 with 1.0vol%. A significant, dose-independent reduction of the cerebral blood flow from 55.8 +/- 8.0 to 46.3 +/- 10.2 (0.25%) to 44.6 +/- 9.5 (0.5vol%) and 44.5 +/- 10.2 ml 100 g-1min-1 (1.0vol%) was observed with halothane. However, a dose-dependent decrease in calculated cerebrovascular resistance was seen at 1.0vol% of halothane. If mean arterial pressure was kept within the normal limits of cerebrovascular autoregulation by the administration of angiotensin-II-amid during 1.0vol% of halothane a marked increase in cerebral blood flow above the baseline value was observed. The lacking increase in cerebral blood flow observed at 1.0vol% of halothane without blood pressure support appeared to be caused by the low cerebral perfusion pressure rather than by vasoconstriction.(ABSTRACT TRUNCATED AT 250 WORDS)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::38fa73aabc48de26f988044ae8ccbe11 https://doi.org/10.1055/s-2007-1000325 Zobrazit plný text záznamu