Structural transitions in erythrocyte membranes in hereditary hemochromatosis

Autor:	Shnyrov Vl, A. A. Deev, A. V. Matveev, Yu. S. Tarakhovskii, V. R. Akoev, S. P. Shcherbinina
Rok vydání:	1997
Předmět:	Isothermal microcalorimetry Chemistry Thermal transition General Medicine medicine.disease General Biochemistry Genetics and Molecular Biology Hemolysis law.invention Membrane Biochemistry law Hereditary hemochromatosis medicine Spectrin In patient Electron microscope
Zdroj:	Bulletin of Experimental Biology and Medicine. 123:242-247
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02445414
Popis:	Changes in the thermal transition parameters of the backbone proteins of the erythrocyte plasma membrane, particularly of spectrin and membrane domain of band3 protein, in patients with hereditary hemochromatosis are demonstrated by differential scanning microcalorimetry. Electron microscopy (the freeze-fracture technique) reveals aggregation of intramembrane particles and their enlargement in erythrocyte membranes from patients in comparison with membranes from healthy donors. These structural changes in the erythrocyte membranes are assumed to contribute to hemolysis and iron overload of the organism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::38f674b21b22e678a946da6461d9d3de https://doi.org/10.1007/bf02445414 Zobrazit plný text záznamu Full text from SpringerLink