Amine-mediated tandem conjugative isomerization-bridging Michael addition: concise synthesis of 1-azabicyclo[3.3.1]nonanes

Autor:	Anh Ngoc Ngo, Zacharias Amara, Delphine Joseph, Khadija El Kassimi, Emmanuelle Drège
Rok vydání:	2012
Předmět:	Tandem Stereochemistry Organic Chemistry Biochemistry Pyrrolidine chemistry.chemical_compound Enantiopure drug chemistry Organocatalysis Drug Discovery Michael reaction Amine gas treating Nonane Isomerization
Zdroj:	Tetrahedron Letters. 53:3296-3300
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.04.069
Popis:	To reach densely functionalized 1-azabicyclo[3.3.1]nonane frameworks synthesis, a stereocontrolled bridging Michael addition involving an unexplored C-5/C-6 disconnection strategy was studied. 1-Azabicyclo[3.3.1]nonane scaffolds have been diastereoselectively elaborated in fairly good yields by two concise pathways implying pyrrolidine derivative organocatalyst or enantiopure 1-phenylethylamine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::38dc27b9c41076fdaf92b4a91520e0bf https://doi.org/10.1016/j.tetlet.2012.04.069 Zobrazit plný text záznamu Full Text from ScienceDirect