Formulation and Evaluation of Floating Drug Delivery System of Antidiabetic Drug
| Autor: | Sudhir R. Iliger, Manjula Lagali, Rekha Hondadakatti |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
010304 chemical physics business.industry media_common.quotation_subject Pharmacology Repaglinide 030226 pharmacology & pharmacy 01 natural sciences Bioavailability 03 medical and health sciences 0302 clinical medicine 0103 physical sciences Drug delivery Medicine business medicine.drug media_common |
| Zdroj: | Research Journal of Pharmaceutical Dosage Forms and Technology. :100-106 |
| ISSN: | 0975-4377 0975-234X |
| Popis: | Repaglinide is an anti-diabetic, oral blood-glucose lowering drug of the meglitinide class used in the management of type-II diabetes mellitus. The present investigation was concerned with the development of the floating matrix tablets, which after oral administration are designed to prolong the gastric residence time and thus, improve the bioavailability of the drug as well as its half life. Repaglinide showed maximum absorption at wavelength 244 nm in 0.5N HCl. Drug-polymer compatibility studies by FT-IR gave confirmation about their purity and showed no interaction between drug and selected polymers. Various formulations were developed by using release rate controlling and gel forming polymers like HPMC (K-4M, K-15M & K-100M) by direct compression method with the incorporation of sodium bicarbonate as gas generating agent. All the formulations had floating lag time below 47.5 seconds and constantly exhibited floating on dissolution medium for more than 24 h. swelling studies indicated significant water uptake and contributed in drug release. The formulation with HPMC K4M (F1, F2 & F3) showed drug release rate between 96 to 99%. The use of HPMC K15M (F4, F5 & F6) have shown drug release rate from 89.3 to 98.2% and formulations with HPMC K100M (F7, F8 & F9) have shown drug release rate between 72 to 84%. From among all the developed formulations, as formulation F5-99% released the drug for longer period of time and it had slightly less floating lag time as compared to other formulations. So, it was selected as the best formulation. It was concluded that the drug release followed zero order kinetic, as the correlation coefficient (R2 value) was higher for zero order release. |
| Databáze: | OpenAIRE |
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