Intercellular adhesion molecule-1 gene polymorphisms in Behçet’s disease

Autor: David H. Verity, Graham R. Wallace, E Kondeatis, Wafa Madanat, H Zureikat, C. A. Kanawati, J. E. Marr, Robert Vaughan, Faisal Fayyad, Miles Stanford
Rok vydání: 2000
Předmět:
Zdroj: European Journal of Immunogenetics. 27:73-76
ISSN: 0960-7420
DOI: 10.1046/j.1365-2370.2000.00202.x
Popis: Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases, including multiple sclerosis and inflammatory bowel disease. The expression of both soluble and tissue ICAM-1 is increased in Behcet's disease (BD) but the contribution of ICAM-1 gene polymorphisms to this disease remains unknown. Associations with BD have been reported for genes within the MHC, including HLA-B51, TNF and MICA, but the role of non-MHC genes in BD remains largely unexplored. We have investigated the frequency of the R/G 241 and K/E 469 ICAM-1 gene polymorphisms in 83 patients with BD disease and 103 healthy controls, all of Palestinian and Jordanian descent, and demonstrated an association between BD and the ICAM-1 E469 allele (Pc = 0.046, OR = 2.1). Among patients, no association was found between the presence of ocular disease and ICAM-1 polymorphisms. While the functional correlate of this polymorphism remains unclear, this finding indicates that a genetic polymorphism in the ICAM-1 gene domain, which is independent of the MHC, may contribute to disease.
Databáze: OpenAIRE