Regulation of peripheral and systemic blood circulation in rats in conditions of acute nitrite hypoxia
| Autor: | Nozdrachev Ad, V. I. Shereshkov, T. E. Shumilova |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Tachycardia
Bradycardia medicine.medical_specialty Regulator Hemodynamics Hypoxia (medical) Biology General Biochemistry Genetics and Molecular Biology Peripheral chemistry.chemical_compound Endocrinology Blood pressure chemistry Internal medicine medicine medicine.symptom Nitrite General Agricultural and Biological Sciences |
| Zdroj: | Biology Bulletin. 39:547-555 |
| ISSN: | 1608-3059 1062-3590 |
| DOI: | 10.1134/s106235901206012x |
| Popis: | Regulation of the systemic and peripheral hemodynamics in the conditions of acute nitrite hypoxia (doses of NaNO2 10, 30, and 50 mg/kg of the body mass) were studied on white male rats. It was shown that NaNO2 causes a quick dose-dependent decrease in the blood pressure with an intensification of the parasympathetic tonus and development of bradycardia. The hemodynamics was restored as the oxygen capacity of the blood decreased with an increase in the sympathetic tonus and development of tachycardia. The role of intracardial metasympathetic structures and the renin-angiotensin system in cardiovascular adaptation to hypoxia was established. Adaptation to nitrite hypoxia is accomplished by a coordinated interaction of neurogenic and humoral factors. A combination of pharmacological agents, which include separate links of regulator systems of the organism, leads to failure of the adaptation process. |
| Databáze: | OpenAIRE |
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