| Autor: |
K A Cartwright, Jeffrey A. Cohen, Michael Singer, N Begg, Clifford Leen, P D Welsby, L Southgate, E B Kaczmarski, W T Todd, Dilip Nathwani, M. J. Wood, J A Innes |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Journal of Infection. 39:1-15 |
| ISSN: |
0163-4453 |
| DOI: |
10.1016/s0163-4453(99)90095-6 |
| Popis: |
Bacterial meningitis in adults (those aged over 15 years) is an uncommon but serious condition. The principles of prevention and treatment are easy to state but, unlike recommendations in guidelines for other conditions, the evidence base for many of our recommendations is lacking or a subject of controversy. The British Infection Society therefore convened a working party comprising clinicians, microbiologists, epidemiologists, general practitioner (GP) and Public Health representatives to assess current evidence and issue a clinically based consensus paper on the management of adult patients with suspected bacterial meningitis which would be useful for non-specialist physicians. The Working Party was aware that they had to make several recommendations using incomplete evidence. evidence from childhood meningitis, or from animal models. The grading of levels of evidence, adapted from AHCPR 1992 ’ . is given in Table I and the grading for our recommendations in Table II. We have included management of septicaemic presentations of meningococcal infection although such patients may not have meningitis. Adults with a meningitic presentation of meningococcal sepsis may have had a relatively mild bacteraemic phase and have a mortality rate of 5% or less whereas those who present with meningococcal septicaemia or sepsis unaccompanied by meningitis may have a mortality rate of 15-40% We have not included advice on management of meningitis following trauma or neurosurgery (except for recommendations for antibiotic treatment of pneumococcal meningitis). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect