| Autor: |
Lynwood H. Smith, Peter G. Werness, J. W. L. Wilson, A. D. Jenkins |
| Rok vydání: |
1984 |
| Předmět: |
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| Zdroj: |
Pathogenese und Klinik der Harnsteine X ISBN: 9783798506299 |
| DOI: |
10.1007/978-3-642-72370-4_32 |
| Popis: |
Calculi formed within the urinary tract are commonly of mixed crystalline composition (1–3). This observation led Modlin in an address to the Royal College of Surgeons in England to suggest that heterogenous nucleation may be an important etiologic factor in the initiation of stone formation in the urinary tract (4). The crystalline mixture of calcium oxalate and hydroxyapatite is especially common. Boyce has shown that at least some hydroxyapatite was present in all the stones he examined, including “pure” calcium oxalate stones. He found that this hydroxyapatite was often located in close association with stone matrix (5). Meyer et al. demonstrated the ability of hydroxyapatite to induce the heterogenous nucleation of calcium oxalate monohydrate in vitro (6). They found that the addition of hydroxyapatite seed crystals to a solution that was supersaturated in terms of calcium oxalate and saturated in terms of hydroxyapatite induced the nucleation of calcium oxalate. Calcium oxalate did not precipitate within the time allowed by the study if no seed crystals were added. The rate of heterogenous nucleation of calcium oxalate was dependent upon the surface area of the seed crystals added. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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