| Autor: | Simon D. Taylor-Robinson, Janet Sargentoni, Sunil Shaunak, J. G. Ainsworth, Claude D. Marcus, Philippa Easterbrook, David J. Bryant, Graeme Frize |
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| Rok vydání: | 1998 |
| Předmět: |
Pathology
medicine.medical_specialty Neurology Metabolite Central nervous system Biology Grey matter computer.software_genre Biochemistry White matter Cellular and Molecular Neuroscience chemistry.chemical_compound medicine.anatomical_structure chemistry Voxel Cortex (anatomy) Centrum semiovale medicine Neurology (clinical) computer |
| Zdroj: | Metabolic Brain Disease. 13:123-136 |
| ISSN: | 0885-7490 |
| Popis: | PURPOSE: To analyze brain metabolite changes in HIV-1-seropositive subjects in order to define whether the neuronal impairment is a localized or more diffuse process. MATERIALS and METHODS: 15 patients and 18 volunteers underwent multivoxel proton magnetic resonance (MR) spectroscopy at 1.5T. Nine patients were classified as being neuropsychiatrically unimpaired and six as having HIV-1-associated dementia on the basis of a full neuropsychological examination. Spectra were analysed from multiple voxels located in the fronto-parietal cortex and white matter at the level of centrum semiovale. RESULTS: A significant reduction in mean peak area ratios of NAA/Cr (p |
| Databáze: | OpenAIRE |
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