Regulation of the Renal Na/K/2Cl Cotransporter Gene
| Autor: | Kimio Tomita, Hiroshi Nonoguchi, Kazuko Itoh, Mika Ikebe |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
inorganic chemicals
medicine.medical_specialty Physiology Potassium Sodium Cell chemistry.chemical_element digestive system environment and public health Internal medicine Genetics medicine Secretion Gene urogenital system Chemistry General Medicine Molecular biology Endocrinology medicine.anatomical_structure Schwartz-Bartter Syndrome Nephrology Cotransporter hormones hormone substitutes and hormone antagonists Bumetanide medicine.drug |
| Zdroj: | Nephron Experimental Nephrology. 6:272-276 |
| ISSN: | 1660-2129 |
| Popis: | The recently cloned bumetanide-sensitive Na/K/2Cl cotransporters (ENCC2-3) and thiazide-sensitive Na/Cl cotransporter (ENCC1) have important roles in sodium chloride absorption and secretion, cell volume regulation, ammonium accumulation in medullary interstitium, and ammonium excretion. Genetic mutations of bumetanide-sensitive Na/K/2Cl cotransporters and thiazide-sensitive Na/Cl cotransporter cause the hereditary hypokalemic alkalosis of some Bartter’s syndrome and Gitelman’s syndrome, respectively. The transporters are sensitive to diuretics and several hormones. Dehydration and acidosis influence the gene expression of ENCC3 but not of ENCC1-2. In contrast, sodium loading increases ENCC2 protein expression in the outer medulla. |
| Databáze: | OpenAIRE |
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