Synthesis of Novel 2-Seleno-1,8-naphthyridines Derivatives

Autor:	Tangali R. Ravikumar Naik, M. Raghavendra, Halehatty S. Bhojya Naik, S. Ramesha, Halehatty R. Prakash Naik
Rok vydání:	2008
Předmět:	Inorganic Chemistry Phenyl hydrazine chemistry.chemical_compound Chemistry Elemental analysis Organic Chemistry Thiazolidine Halogen Proton NMR Organic chemistry Spectral data Biochemistry Medicinal chemistry
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 183:1968-1974
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426500701839601
Popis:	Synthesis of series of new 2-phenyl-3-(2-seleno-1,8-naphthyridin-3-yl)-2,3,3a,6-tetrahydro-5H-pyrazolo[3,4-d][1,3]thiazol-5-ones (4a–e) has been reported. The replacement of halogen with NaHSe in the substituted 2-chloro-3-formyl-1,8-naphthyridi afforded 2-seleno-3-formyl-1,8-naphthyridins (2a – e). The reaction between (2a–e) and 1,3-thiazolidine-2,4-dione produced corresponding derivatives of substituted compounds (3a–e), which on reflux with phenyl hydrazine in DMF to generate (4a–e), with good to excellent yields. Structure of newly synthesized compounds were established based on elemental analysis, IR, 1H NMR, and mass spectral data.
Databáze:	OpenAIRE
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