| Autor: |
Dmitriy Romanov, Elena Butenko, Georgy Bakhtadze, Tatiana P. Shkurat |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Gene Reports. 17:100508 |
| ISSN: |
2452-0144 |
| DOI: |
10.1016/j.genrep.2019.100508 |
| Popis: |
The problem of growth regulation in mammals is one of the long-standing mysteries in biology. The growth rate is high in early postnatal life, but then decreases and eventually ceases in multiple tissues, determining adult body size, in all mammalian species. It has been shown that age-related changes in growth rate in mammals are associated with declining in expression of large set of growth-promoting genes. On the other hand, the somatotropic axis genes are known to be involved in the systemic growth regulation. We have found very strong correlation between some morpho-physiological traits of mammals and genome distances between conserved elements in neighborhoods of these genes among mammals. We believe that genome distance between some regulatory sites of the gene may determine gene expression and eventually affect the phenotype. We first suggest that the difference of these distances among mammals can cause evolutionary variation of morpho-physiological traits. We have also proposed the particular molecular mechanisms of regulation of these genes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect