Synthetic analogs of phytanic acid and their effect on human hepatic cholesterol esterase in vitro
Autor: | G. V. Kryshtal, L. V. Filatova, V. V. Tertov, Galina M. Zhdankina, A. G. Nigmatov, Edward P. Serebryakov |
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Rok vydání: | 2006 |
Předmět: | |
Zdroj: | Pharmaceutical Chemistry Journal. 40:23-28 |
ISSN: | 1573-9031 0091-150X |
Popis: | Ten acyclic isoprenoid fatty acids were synthesized and tested in vitro as possible regulators of the cholesterol/cholesteryl alkanoate ratio in blood serum lipoproteins. Racemic C20 analogs of (3R/S,7R, 11R)-3,7,11,15-tetramethylhexadecanoic (phytanic) acid proved to be powerful activators of human liver cholesterol esterase (HLCE) in vitro. Achiral (E,E)-5,9,13-trimethyltetradeca-4,8,12-trienoic (farnesylacetic) acid, a low-toxicity antiulcerative substance, also significantly accelerates the HLCE-catalyzed hydrolysis of cholesteryl palmitate. |
Databáze: | OpenAIRE |
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