Synthetic analogs of phytanic acid and their effect on human hepatic cholesterol esterase in vitro

Autor:	G. V. Kryshtal, L. V. Filatova, V. V. Tertov, Galina M. Zhdankina, A. G. Nigmatov, Edward P. Serebryakov
Rok vydání:	2006
Předmět:	Pharmacology Phytanic acid Cholesterol Pyridinium chlorochromate Esterase Terpenoid In vitro chemistry.chemical_compound Hydrolysis Blood serum Biochemistry chemistry Drug Discovery lipids (amino acids peptides and proteins)
Zdroj:	Pharmaceutical Chemistry Journal. 40:23-28
ISSN:	1573-9031 0091-150X
Popis:	Ten acyclic isoprenoid fatty acids were synthesized and tested in vitro as possible regulators of the cholesterol/cholesteryl alkanoate ratio in blood serum lipoproteins. Racemic C20 analogs of (3R/S,7R, 11R)-3,7,11,15-tetramethylhexadecanoic (phytanic) acid proved to be powerful activators of human liver cholesterol esterase (HLCE) in vitro. Achiral (E,E)-5,9,13-trimethyltetradeca-4,8,12-trienoic (farnesylacetic) acid, a low-toxicity antiulcerative substance, also significantly accelerates the HLCE-catalyzed hydrolysis of cholesteryl palmitate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::38b613720aab98f2df7ba8f4c7146856 https://doi.org/10.1007/s11094-006-0050-6 Zobrazit plný text záznamu Plný text ve formátu PDF