| Autor: |
Andrea Paola Rodriguez, Rossana E. Madrid, Hitoshi Nagatsuka, Carmelo Jose Felice, Hidetsugu Tsujigiwa, Maria Alejandra Sanchez, Miho Inoue, Betiana Felice |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
IFMBE Proceedings ISBN: 9783319131160 |
| Popis: |
In recent years, calcium titanate (CaTiO3) and carbon-containing materials have gained much attention in a number of biomedical material researches. To maximize the advantages of both materials, we developed a novel alkoxide method to get “calcium titanate with calcium carbonate” (CaTiO3-CaCO3). Thus, our previous result indicated that calcium carbonate could play a key role in the cell response of CaTiO3 material. In the present study we evaluated the effect of sintering time of CaTiO3-CaCO3 in osteoblastic response of KUSA/A1 cells. We examined the material characterization as well as cellular proliferation and mineralization of KUSA/A1 cells cultured with the materials. The results showed that Ca-TiO3-CaCO3 material sintered during 30 min, has better influ-ence on the bone marrow stromal cells for their proliferation and mineralization compared to CaTiO3-CaCO3 sintered at 2 and 10 h. These results suggest that sintering time could be directly related to the amount of carbon within CaCO3 being crucial in cell response. In conclusion, our preliminary find-ings indicate that CaTiO3-CaCO3 could play a more dominant and favorable effect on cell response when sintered for 30 minutes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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