The Mechanisms and Overcoming Strategies of the Radioresistance in Head and Neck Cancer

Autor: Myung Woul Han
Rok vydání: 2023
Předmět:
Zdroj: Korean Journal of Otorhinolaryngology-Head and Neck Surgery. 66:295-301
ISSN: 2092-5859
DOI: 10.3342/kjorl-hns.2022.01102
Popis: Radiotherapy plays an important role in the treatment of most of solid tumors including head and neck squamous cell carcinoma (HNSCC). Radioresistance can lead to locoregional recurrence and distant metastases. Despite significant progress in research of radioresistance, its prediction and overcoming strategies remain challenging. This review describes the potential biomarkers correlated to the radioresistance and complex signal pathway in mechanism of radioresistance focusing on the PI3K and EphA3 pathway.
Databáze: OpenAIRE