Diagnostische und prognostische Bedeutung massiv erhöhter Glutamat-Dehydrogenase-Aktivität im Serum

Autor:	E. Schmidt, Frank Schmidt, G. Chemnitz, J. Lobers
Rok vydání:	2008
Předmět:	medicine.medical_specialty Pathology business.industry Mortality rate Retrospective cohort study General Medicine medicine.disease Gastroenterology Transaminase Excretion Internal medicine Shock (circulatory) medicine Respiratory system medicine.symptom Viral hepatitis business Perfusion
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 109:1789-1793
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1069454
Popis:	In a retrospective analysis of case reports of 115 patients with glutamate-dehydrogenase (GLDH) activity in serum of more than 100 U/l in 1979-1981, the most common causes of this increase were: acute right heart failure (28 patients), protracted septic-toxic circulatory failure (20), obstructive jaundice (18) and severe respiratory insufficiency (16), i. e. diseases causing perfusion or excretion disorders in the liver. The ratio of GLDH activity to transaminase activity provided a reliable separation of acute viral hepatitis, but not of different forms of perfusion disorders. The correlation between GLDH activity and death rate, especially in acute right-heart failure, is of prognostic value.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::38a3ed28e9b7f9919bb15249aff9674f https://doi.org/10.1055/s-2008-1069454 Zobrazit plný text záznamu