The effect of the glycyl-proline dipeptide on the metabolism of neuroactive amino acids and indices of energy turnover in the neocortex of rats after experimental brain ischemia

Autor:	A. G. Moiseenok, N. Z. Bashun, E. M. Doroshenko, E. F. Raduta, Zh. I. Balash, V. P. Golubovich, N. P. Kanunnikova
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Alanine Taurine Dipeptide Glutamate dehydrogenase Glutamate decarboxylase Glutamate receptor Biochemistry Amino acid Cellular and Molecular Neuroscience chemistry.chemical_compound chemistry Glycine Molecular Biology
Zdroj:	Neurochemical Journal. 7:39-44
ISSN:	1819-7132 1819-7124
DOI:	10.1134/s1819712412040046
Popis:	We studied the effects of the glycyl-proline dipeptide (Gly-Pro) at a dose of 3 mg/kg on the contents of neuroactive amino acids, including aspartate, glycine, alanine, taurine, GABA, and glutamate, the activity of the enzymes of the GABA shunt, such as GABA-transaminase, succinic semialdehyde dehydrogenase, and glutamate decarboxylase, and enzymes of glutamate metabolism, such as glutamate dehydrogenase and alanine and aspartate transaminases in the neocortex of rats subjected to 6-h brain ischemia. We used three means of dipeptide administration, including intraperitoneal, subconjunctival, and intranasal. We found that the protective anti-ischemic effect of Gly-Pro was mostly expressed after intranasal administration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::38a3c0ba09035725116c6154e8ff911e https://doi.org/10.1134/s1819712412040046 Zobrazit plný text záznamu Full text from SpringerLink