A Radical Cascade Enabling Collective Syntheses of Natural Products
| Autor: | Qilong Zhou, Xiaohan Zhou, Hao Song, Xiaobei Wang, Wentao Liu, Xiang Dai, Shuqing Wang, Dongliang Xia, Ruijie Zhou, Wenfang Qin, Xiao-Yu Liu, Hui-Jing Wang, Ling Tan, Yong Qin, Dan Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
Monoterpenoid Indole Alkaloids
010405 organic chemistry Chemistry General Chemical Engineering Biochemistry (medical) Total synthesis General Chemistry 010402 general chemistry 01 natural sciences Biochemistry Natural (archaeology) 0104 chemical sciences Cascade Materials Chemistry Environmental Chemistry Organic chemistry Biochemical engineering |
| Zdroj: | Chem. 2:803-816 |
| ISSN: | 2451-9294 |
| DOI: | 10.1016/j.chempr.2017.04.007 |
| Popis: | Summary Natural products have long been important inspirations for the development of chemical methodologies, theories, and technologies, and ultimately, discoveries of new drugs and materials. Chemical syntheses have traditionally yielded individual or small groups of natural products; however, methodology development allowing the synthesis of a large collection of natural products remains scarce. Here, we report an efficient photocatalytic radical cascade method that enables access to libraries of chiral and multiple-ring-fused tetrahydrocarbolinones. The radical cascade can controllably introduce complexity and functionality into products with excellent chemo-, regio-, and diastereoselectivity. The power of this distinct method has been demonstrated by the efficient syntheses of 33 monoterpenoid indole alkaloids belonging to four families. |
| Databáze: | OpenAIRE |
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