Small Molecules Modulating Mammalian Biological Clocks: Exciting New Opportunities for Synthetic Chemistry
| Autor: | Kazuma Amaike, Nicola Stephanie Skoulding, Tsuyoshi Oshima, Yoshifumi Toyama, Kenichiro Itami, Tsuyoshi Hirota |
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| Rok vydání: | 2020 |
| Předmět: |
Chronobiology
Biological studies Biological clock General Chemical Engineering Biochemistry (medical) Circadian clock Chemical biology 02 engineering and technology General Chemistry Biology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Small molecule 0104 chemical sciences Materials Chemistry Environmental Chemistry 0210 nano-technology Molecular clock Neuroscience |
| Zdroj: | Chem. 6:2186-2198 |
| ISSN: | 2451-9294 |
| DOI: | 10.1016/j.chempr.2020.08.011 |
| Popis: | Summary The circadian clock is an intrinsic time-keeping system that controls daily rhythms in almost all living organisms on the earth. Daily rhythms are observed in various life phenomena, such as sleep-wake cycles, body temperature, blood pressure, and hormone secretion in animals, and stomatal movements and photosynthetic activity in plants. Therefore, controlling the circadian clock in a precise manner will make significant contributions in the elucidation of their molecular mechanisms, as well as to medicine and agriculture. Genetic and molecular biological studies have made substantial progress in understanding of molecular clock mechanisms. For further investigation of the basic mechanisms as well as for therapeutic applications, small-molecule compounds will provide unique opportunities. In this perspective, we highlight chemical biology approaches toward mammalian circadian clock modulation by using small synthetic molecules. |
| Databáze: | OpenAIRE |
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