The Si-2,4,6-Trimethoxyphenyl Moiety as a Novel Protecting Group in Organosilicon Chemistry: Alternative Synthesis of rac-Sila-venlafaxine

Autor:	Reinhold Tacke, Christian Burschka, Jürgen O. Daiss, Martin Penka
Rok vydání:	2004
Předmět:	Inorganic Chemistry chemistry.chemical_compound Silacyclobutane Chemistry Stereochemistry Organic Chemistry Sila-Venlafaxine Moiety Physical and Theoretical Chemistry Noradrenaline reuptake inhibitor Protecting group Organosilicon
Zdroj:	Organometallics. 23:4987-4994
ISSN:	1520-6041 0276-7333
Popis:	The Si-2,4,6-trimethoxyphenyl (Si-2,4,6-TMOP) moiety is claimed to be an effective protecting group for synthetic organosilicon chemistry. To demonstrate its high synthetic potential, the Si-2,4,6-TMOP protecting group has been used for a novel multistep synthesis of rac-sila-venlafaxine (a sila-analogue of the serotonin/noradrenaline reuptake inhibitor rac-venlafaxine), starting from 1,1-dichloro-1-silacyclohexane. In addition, the Si-2,4,6-TMOP moiety has been used as a protecting group in silacyclobutane chemistry.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3884644140b5e22f9ff7a0074639efd5 https://doi.org/10.1021/om040087n Zobrazit plný text záznamu