In vitro pharmacological evaluation of the dichloromethanol extract fromSchinus molle l

Autor:	Sara Calatayud, L. Moreno, E. Primo-Yúfera, Belén Beltrán, Juan V. Esplugues, R. Bello
Rok vydání:	1998
Předmět:	Pharmacology biology Ileum Biological activity Anatomy Pharmacognosy biology.organism_classification Schinus molle Guinea pig chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Serotonin Histamine Acetylcholine medicine.drug
Zdroj:	Phytotherapy Research. 12:523-525
ISSN:	1099-1573 0951-418X
DOI:	10.1002/(sici)1099-1573(199811)12:7<523::aid-ptr337>3.0.co;2-a
Popis:	The pharmacological activity of the dichloromethanol extract of Schinus molle L. (SM-DCM) was analysed in in vitro models. Preincubation of the isolated guinea-pig ileum or rat uterus preparations with the extract (100 μg/mL) abolished the contractile effects of histamine and serotonin respectively. At the same dose, the extract partially reduced the contractile effects of acetylcholine on the isolated rat duodenum. A 10 μg/mL dose showed an inhibitory effect on histamine and serotonin, but not on acetylcholine-induced contractions (NS). No significant effect was found with a 1 μg/mL dose. © 1998 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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