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This work is to measure certain biochemical parameters and to search the blood, intestinal and pinworm parasites, yeasts and foods parameters in type 1 diabetics and their siblings. The study population is constitute of 28 Type 1 diabetics (TD1) and 59 siblings aged between 5 to 21 years, including 41 boys and 46 girls, a sex ratio of 0.89. The mean age of T1D was 12.62 ± 2.75 years and the mean age of the siblings of diabetic’s patients was 12.13 ± 4.94 years. TD1 were recruited in C. H. U of Yopougon and Treichville and two NGOs of Cote d’Ivoire. The biochemical parameters were assayed at the laboratory of biochemistry of C. H. U Habib Bourguiba of SFAX, Tunisia. Research of Infectious and foods parameters was carried out Institute Pasteur of Cote d’Ivoire. Study takes place January 2014 to April 2016. Biochemical parameters carried out with Cobas 6000 (Roche / Hitachi). Infectious parameters research was done by direct and Ritchie simplified method, Kato test and scotch anal test. Foods parameters were researched by survey. Phosphorus value was three times greater than normal in certain siblings. There was no difference on the concentration of the biochemical parameters between TD1 and their siblings (p>0.05). There were presence of blood, intestinal, pinworms parasites and yeast in TD1 and their siblings and unbalanced diet (carbohydrate, protein and lipid) with their siblings (p |