Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers)
| Autor: | Ahmed Serag Habib, Sahar M. El-Sheikh, Hend Mohamed Helmy, Taissir A. Omar |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Methyltransferase Methyl guanine methyl transferase General Medicine Biology medicine.disease_cause digestive system diseases stomatognathic diseases Cancer research medicine Cytotoxic T cell Immunohistochemistry Basal cell Carcinogenesis neoplasms Carcinogen Immunostaining |
| Zdroj: | American Journal of Life Sciences. 2:217 |
| ISSN: | 2328-5702 |
| DOI: | 10.11648/j.ajls.20140204.15 |
| Popis: | Objectives: O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic, carcinogenic, and cytotoxic adducts from O6-methylguanine in DNA through a direct reversal mechanism. Decreased expression of MGMT has been reported in a variety of human malignant tumors. The purpose of this study was to clarify the correlation of MGMT expression levels in oral squamous cell carcinoma (OSCC) and cigarette smoking. Study Design: MGMT protein expression in 22 cases of oral squamous cell carcinoma by immunohistochemistry was investigated. Correlation with detailed tobacco history was then tested by statistical analysis. Results: All the non smoker OSCC cases showed positive immunoexpression. However 3 cases of the smoker patient revealed a weak positive immunostaining with only sporadic cells at the periphery. Conclusion: The results suggest that the absence of MGMT expression is related strongly to tobacco smoking and, thus, might be a significant event in oral carcinogenesis. |
| Databáze: | OpenAIRE |
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