| Autor: |
Bindu Madhavi Boddupalli, Bala Subramaniam, Ravinder Nath Anisetti, Ramalingam Ramani |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Asian Pacific Journal of Tropical Biomedicine. 2:S1237-S1240 |
| ISSN: |
2221-1691 |
| DOI: |
10.1016/s2221-1691(12)60392-x |
| Popis: |
Objective In the recent years of research, the interest on herbal medicine is continuously increasing. Piperine is an alkaloid extracted from ripen fruits of Piper nigram and was proved in literature for its hepato protective and anti ulcer properties majorly through anti oxidant capability. Methods In the present investigation gastro retentive, both floating and mucoadhessive microspheres are evaluated for the hepato protection in paracetamol induced model and gastric protection in rats and a comparison was done with conventional microspheres and pure form of piperine. Results The results clearly showed the significant decrease in the serum levels of the marker enzymes in hepato protective study supported by histopathology along with reduced ulcer index in anti ulcer activity. Conclusion This clearly indicates that there is an increase in both activities of floating microspheres, mucoadhessive microspheres when compared with the PP and conventional microspheres. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
