Inhibition of rat brain monoamine oxidase-B by some monoamine reuptake inhibitors as antidepressants

Autor:	Yuichiro Arai, N. Satoh, N. Fujishiro, Takeshi Tadano, M. Takeda, Osamu Nakagawasai, N. Uchida, Hajime Yasuhara
Rok vydání:	2002
Předmět:	Pharmacology Chemistry Monoamine oxidase General Neuroscience Nomifensine Monoamine neurotransmitter medicine Serotonin Monoamine oxidase B Reuptake inhibitor Maprotiline Zimelidine medicine.drug
Zdroj:	Biogenic Amines. 17:25-30
ISSN:	1569-3910 0168-8561
DOI:	10.1163/15693910260519274
Popis:	Monoamine oxidase (MAO) activities in rat forebrain homogenate were determined by using serotonin and benzylamine as respective substrates of MAO-A and -B. Effects of the antidepressants, imipramine, maprotiline, nomifensine and zimelidine on MAO activity were determined. All of these compounds inhibited both MAO-A and -B activity, but the inhibition was not strong. The inhibitory potency of MAO-A and -B was not changed by preincubation of homogenates with these compounds. Each compound competitively inhibited MAO-A, but MAO-B inhibition was shown to be mixed-type inhibition by Lineweaver-Burk plots.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::38655c29a0d38f3aca67f630a74831a4 https://doi.org/10.1163/15693910260519274 Zobrazit plný text záznamu Plný text ve formátu PDF