Telescoped continuous flow synthesis of phenyl acrylamide
| Autor: | Jatuporn Salaklang, Erika Mertens, Rudy Dams, Tanja Junkers, Veronique Maes, Wim Dermaut |
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| Rok vydání: | 2020 |
| Předmět: |
Fluid Flow and Transfer Processes
Green chemistry 010405 organic chemistry business.industry Chemistry Organic Chemistry Flow chemistry 010402 general chemistry 01 natural sciences Continuous production 0104 chemical sciences chemistry.chemical_compound Chemistry (miscellaneous) Hazardous waste Reagent Yield (chemistry) Organic synthesis Microreactor Process engineering business |
| Zdroj: | Journal of Flow Chemistry. 10:673-679 |
| ISSN: | 2063-0212 2062-249X |
| DOI: | 10.1007/s41981-020-00113-6 |
| Popis: | Functional acrylamides are valuable intermediates for organic synthesis and building blocks in many industrial areas, like polymer synthesis, fine chemicals and pharmaceutics. The conventional batch reaction copes with some safety issues, due to the intrinsic reactivity and careful handling of the reagents. Moreover, the hazardous solvents used and the energy consumed have an enormous environmental impact. The development of an efficient and robust continuous flow process, allowing a safe and on-demand synthesis of acrylamides with high yield leads the way to a more sustainable chemistry. Two alternative synthesis routes for the preparation of N-phenyl acrylamide, but applicable as a continuous production process, are presented: both based on the Schotten-Baumann reaction, one starting from 3-chloropropanoyl chloride and the other starting from acrylic acid. The latter reaction, with a laboratory throughput of 16.5 g·h−1, low operation temperatures and the use of less hazardous chemicals, provides an efficient and sustainable alternative synthesis route of the desired acrylamides, minimizing side-products and enabling a safe and convenient scale-up. |
| Databáze: | OpenAIRE |
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