Studies on the coagulant effects of boomslang (Dispholidus typus) venom
| Autor: | E.D. Gomperts, P.M. Atkinson, M.C. Gaillard, B.A. Bradlow |
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| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Boomslang biology Factor X Phospholipid chemistry.chemical_element Venom Hematology Calcium Pharmacology biology.organism_classification medicine.disease complex mixtures chemistry.chemical_compound Endocrinology Coagulation chemistry hemic and lymphatic diseases Internal medicine Vitamin K deficiency medicine Factor IX medicine.drug |
| Zdroj: | Clinical & Laboratory Haematology. 2:317-331 |
| ISSN: | 0141-9854 |
| DOI: | 10.1111/j.1365-2257.1980.tb00840.x |
| Popis: | Summary Evidence based on coagulation and biochemical studies indicated that the coagulant effect of boomslang venom was chiefly due to its ability to activate prothrombin. It was also able to activate prethrombin I, factor X and possibly factor IX as well. Other effects of the venom on the coagulation system seemed to be of little consequence in relation to its major actions. The action of the venom on prothrombin did not require the presence of calcium ions, phospholipid or any other coagulation factors. Furthermore, the venom was able to split the acarboxy form of prothrombin. The venom could, therefore, be used as a reagent for the detection of acarboxy prothrombin in vitamin K deficiency or antagonism. |
| Databáze: | OpenAIRE |
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