| Autor: |
Soo-Cheon Chae, Hun-Soo Kim, Jae-Hoon Lee, Hyung-Bae Moon, Ji-In Yu, Ki-Jung Yun, Weon-Cheol Han |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Journal of Life Science. 19:299-304 |
| ISSN: |
1225-9918 |
| DOI: |
10.5352/jls.2009.19.3.299 |
| Popis: |
Interleukin 27 (IL-27) was discovered as a heterodimeric cytokine of the IL-12 family, and is composed of two subunits - Epstein-Barr virus induced gene 3 (EBI3) and p28. It acts as a versatile cytokine in the early regulation of Th1 initiation and in the negative regulation of the Th2 factor GATA binding protein 3 (GATA-3). This cytokine is mediated by the IL-27 receptor (WSX-1), which is highly expressed on CD4? T lymphocytes and NK cells. We previously identified four polymorphisms in the human IL-27p28 gene and suggested that the polymorphism of IL-27p28 is associated with susceptibility to asthma. To determine whether these IL-27p28 SNPs are associated with susceptibility to allergic rhinitis, the genotype and allele frequencies of IL-27p28 SNPs were analyzed between allergic rhinitis patients and healthy controls. Although the genotype and allele frequencies of IL-27p28 SNPs in allergic rhinitis patients were not significantly different from those of the control group, there was a suggestive difference (P=0.037) between these groups in total serum IgE levels in the g.2905T＞G SNP of the IL-27p28 gene. Our result implies that the g.2905T＞G SNP of the IL-27p28 gene might have an affect on IgE production in allergic rhinitis patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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