Clinical Study on Concentration of Antibiotics in Bone Tissue After Intravenous Regional Injection

Autor:	Akifumi Tani, Yasuhiro Shimizu, Yasuyuki Abe, Tetsuo Nakano, Haruhiko Chuma
Rok vydání:	1997
Předmět:	medicine.medical_specialty Tourniquet medicine.drug_class business.industry Antibiotics Serum concentration Bone tissue Surgery Pharmacokinetic analysis Clinical study medicine.anatomical_structure Anesthesia medicine business
Zdroj:	Orthopedics & Traumatology. 46:305-309
ISSN:	1349-4333 0037-1033
DOI:	10.5035/nishiseisai.46.305
Popis:	For treatment of orthopaedic infections, antibiotics are usually administered parenterally. We report an effective technique for infective prophylactic countermeasures. Antibiotics (CZON 100-1000mg, CEZ 1000mg, ISP 40mg) were administered by intravenous regional injection after tourniquet to 36 patients and pharmacokinetic analysis was performed to assess concentration in bone tissue. The serum concentration in bone tissue of CZON, CEZ and ISP was 133-2430μg/ml, 2426.1μg/ml (mean) and 129.5μg/ml (mean). After tourniquet removal, the serum concentration in body blood of ISP was 2.7μg/ml (mean). The result suggested that a much higher concentration of antibiotics in bone tissue and a much lower concentration in blood after tourniquet removal were obtained, and side effects did not appear. This technique was demonstrated to be extremely useful for infective prophylactic countermeasures.
Databáze:	OpenAIRE
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