Abstract 44: Associations of Atrial Fibrillation, Neuroimaging Measures of Cerebrovascular Disease and Alzheimer’S Disease-related Pathology, and Cognitive Impairment
| Autor: | Jonathan Graff-Radford, Rosebud Roberts, Malini Madhavan, Alejandro Rabinstein, Ruth Cha, Prashanthi Vemuri, Kejal Kantarci, Michelle Mielke, Val Lowe, Jeffrey Gunter, Matthew Senjem, Vernon S Pankratz, David Knopman, Ronald C Petersen, Clifford Jack |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Stroke. 46 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/str.46.suppl_1.44 |
| Popis: | The objective of this study was to investigate the cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer’s disease-related pathology, and their interaction with cognitive impairment. MRI scans of non-demented individuals (n=1044) from the population-based Mayo Clinic Study of Aging were analyzed for infarctions, total grey matter, hippocampal and white matter hyperintensity volumes. A subset of 496 individuals underwent FDG and C-11 Pittsburgh compound B (PiB) PET scans. We assessed the associations of atrial fibrillation with i) categorical MRI measures (cortical and subcortical infarctions) using multivariable logistic regression models, and with ii) continuous MRI measures ( hippocampal, total grey matter, and white matter hyperintensity volumes) and FDG-PET and PiB-PET measures using multivariable linear regression models, and adjusting for confounders. Among participants who underwent MRI (median age, 77.8, 51.6% male), 13.5% had atrial fibrillation. Presence of atrial fibrillation was associated with subcortical infarctions (odds ratio [OR], 1.83; p=0.002), cortical infarctions (OR, 1.91; p=0.03), total grey matter volume (Beta [β], -.025, p |
| Databáze: | OpenAIRE |
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