The Effect of Spironolactone on the Pathogenesis of Ligatureinduced Alveolar Bone Loss in Wistar Rats
| Autor: | Verzeletti, G N, Gaio, E J, Rösing, C K |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| DOI: | 10.23675/sjlas.v35i3.148 |
| Popis: | Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that has a straight relationship with tissue destruction in the pathogenesis of periodontitis. Inhibitory effects of TNF production have been attributed to spironolactone. The aim of this study was to evaluate the effect of spironolactone on the pathogenesis of ligature-induced alveolar bone loss in rats. Experimental periodontitis was induced in 38 Wistar rats by ligature placement in the left second maxillary molar. The contra-lateral maxillary molar served as intragroup control. Animals were randomly divided into 4 groups and treated with spironolactone (50, 100, 200 mg·kg-1) or saline. Morphometrical registration of maxillary alveolar bone was performed after 28 days of experimental periodontitis. Intra-group comparisons showed significantly higher alveolar bone loss mean values in maxillary sides with ligature (paired sample t test, p0.05). Although spironolactone has recognized TNF-inhibitory properties, the possibility of its use on modulation of host immune-inflammatory response in periodontal disease was not confirmed. Scandinavian Journal of Laboratory Animal Sciences, Vol 35, No 3 (2008) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|