Impaired Dynamic Thiol/disulfide Homeostasis and Pro-inflammatory Parameters in Hand Osteoarthritis
| Autor: | Leyla Didem Kozaci, Betül Özbek Ipteç, Gamze Avcioglu, Ömer Faruk Şendur |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test business.industry Paraoxonase Malondialdehyde medicine.disease_cause Arylesterase Pathogenesis chemistry.chemical_compound Endocrinology chemistry Erythrocyte sedimentation rate Myeloperoxidase Internal medicine biology.protein medicine Ceruloplasmin business Oxidative stress |
| Zdroj: | International Journal of Innovative Approaches in Science Research. 2:140-151 |
| ISSN: | 2602-4535 2602-4810 |
| Popis: | Background: Reactive oxygen species have a role in pathogenesis of osteoarthritis. The main objective of this study was to determine other oxidant/antioxidant substances and inflammatory markers in hand osteoarthritis patients. Methods: Thirty healthy controls and 50 patients with hand osteoarthritis (HOA) were included in the study. All patients were questioned about age, sex, history of the symptoms, presence of sensitive and swollen joints, smoking habits, other systemic diseases and medications. Serum thiol-disulfide homeostasis tests (TDHT), catalase (CAT), ceruloplasmin (Cp), arylesterase (ARES), paraoxonase (PON), stimulated paraoxonase (SPON), total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), myeloperoxidase (MPO), routine biochemistry tests and inflammatory markers: Interleukin-1b (IL-1b), interleukin-6 (IL-6), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured. Results: MPO, TDHT, MDA, MPO and inflammatory markers (IL-6, CRP and ESR) were significantly different in HOA patients from those in control group (p=0.005; p=0.001; p=0.014; p=0.005; p=0.012; p=0.003 and p |
| Databáze: | OpenAIRE |
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