PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA

Autor:	Harmesh Naik, A. Yagoda, Adil Akhtar, Lehr Je, Kenneth J. Pienta, D. Petrylak
Rok vydání:	1995
Předmět:	Cancer Research Oncogene Cell Cancer Cell cycle Biology medicine.disease chemistry.chemical_compound Prostate cancer medicine.anatomical_structure Oncology chemistry Gossypol LNCaP medicine Cancer research Prostate neoplasm
Zdroj:	International Journal of Oncology.
ISSN:	1791-2423 1019-6439
Popis:	Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vive, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::382ad9b3a36dca32f4b33bbcb4126e52 https://doi.org/10.3892/ijo.6.1.209 Zobrazit plný text záznamu