| Autor: |
Iordana Astefanoaei, Alexandru Stancu |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
TIM 19 PHYSICS CONFERENCE. |
| ISSN: |
0094-243X |
| DOI: |
10.1063/5.0001011 |
| Popis: |
In the Magnetic Hyperthermia, the computation of the magnetic nanoparticle (MNP) doses which induce the therapeutic temperature field within tumor volume is an important task for Hyperthermia Planning Therapy (HPT). This paper develops a computational model used as a thermal analysis tool to compute the MNP doses which induce the appropriate thermal damage of the malignant tissue when an external time-dependent magnetic field is applied. Using the realistic data from the computed tomography scan (2D – CT scan), the therapeutic temperature field in the hyperthermic range (40 ÷ 46°C) was analyzed using the proper physical characteristic parameters. In the Arrhenius formulation, the thermal analysis based on the thermal damage dependent blood perfusion was compared to the one with constant blood perfusion. The strong dependence of the perfusion profile on the cooling mechanism is discussed based on the temperature field model results. The control of this supplementary effect is very important for the efficiency of the therapy and for the protecting of the healthy surrounding tissues. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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