Rôle catalytique de l'eau et des sels lors de l'hydrolyse alcaline des esters en milieu hydro-alcoolique

Autor:	J. Corset, Gerard Nee, B. Tchoubar, G. Leny, M. L. Josien, R. M. Moravie
Rok vydání:	1976
Předmět:	Hydrogen bond Organic Chemistry Ethyl acetate Infrared spectroscopy Biochemistry Medicinal chemistry Solvent chemistry.chemical_compound Reaction rate constant chemistry Nucleophile Drug Discovery Molecule Organic chemistry Alkaline hydrolysis
Zdroj:	Tetrahedron. 32:693-700
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)93793-7
Popis:	Infrared spectra of esters in water-alcohol mixtures, with or without added salts, indicate the formation of 1:1 or 1:2 complexes through hydrogen bonding between the ester carbonyl group and the proton donor molecules of the solvent, as well as the formation of a donor-acceptor complexes with Li + or Ba 2+ . These complexes facilitate nucleophilic attack at the carbon of the carbonyl group by hydroxyl anions. Depending on the water content of the mixture, the addition of LiCIO 4 increases or decreases the rate constant of the reaction. The displacement of equilibria between different entities explains a higher rate constant in water-tert-butanol than in water-methanol mixtures of the alkaline hydrolysis of ethyl acetate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::38299d8dc2fb42bde1d401d81e949a94 https://doi.org/10.1016/s0040-4020(01)93793-7 Zobrazit plný text záznamu