Synthesis of tritiated 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)1
| Autor: | Akira Kawase, Yoshihiko Ishitani, Hiroyoshi Watanabe, Tetsuya Mitsui, Noboru Kubodera, Ken Okano, Kazumi Morikawa |
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| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Vitamin Chemistry Stereochemistry Sodium medicine.medical_treatment Organic Chemistry Iodide chemistry.chemical_element Biochemistry Chemical synthesis Analytical Chemistry Steroid chemistry.chemical_compound Drug Discovery Side chain medicine Radiology Nuclear Medicine and imaging Specific activity Tritium Spectroscopy |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 42:519-525 |
| ISSN: | 1099-1344 0362-4803 |
| Popis: | The synthesis of tritiated 1α-25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71), [2β-(3-3H)]ED-71 ((3) and [26,27-3H6]ED-71 (4) is described. The former was prepared by reduction of a precausor containing a formyl group in the A-ring part with sodium borotritiide while the latter was labeled in the side chain using tritiated methylmagnesium iodide. The specific activity of 3 was 13.2 Ci/mmol and that of 4 138.0 Ci/mmol. Copyright © 1999 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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