Delayed apperance of anti-myelin-associated glycoprotein antibodies in a patient with chronic demyelinating polyneuropathy
| Autor: | Francesc Graus, Teresa Ribalta, Esteban Muñoz, Eduard Tolosa, M A de la Fuente, A. J. Steck, T. Gallart, J. A. Bombi, Francesc Valldeoriola |
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| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
biology Myelin-associated glycoprotein medicine.drug_class business.industry Chronic inflammatory demyelinating polyneuropathy medicine.disease Monoclonal antibody Myelin medicine.anatomical_structure nervous system Neurology chemistry Immunopathology Immunology medicine biology.protein Neurology (clinical) Antibody Glycoprotein business Polyneuropathy |
| Zdroj: | Annals of Neurology. 34:394-396 |
| ISSN: | 0364-5134 |
| DOI: | 10.1002/ana.410340314 |
| Popis: | A patient who had a polyneuropathy compatible with a chronic inflammatory demyelinating polyneuropathy and was initially negative for anti-myelin-associated glycoprotein (MAG) antibodies developed a double monoclonal gammopathy, IgM kappa and IgM lambda, two years after the diagnosis. The IgM kappa, but not the IgM lambda, exhibited strong anti-MAG antibody activity. The late appearance of the anti-MAG immunoreactivity suggests that in patients with an initial diagnosis of chronic inflammatory demyelinating polyneuropathy, the search for anti-MAG antibodies should be repeated during the course of the neuropathy. |
| Databáze: | OpenAIRE |
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