Association between paraoxonase-1 gene promoter -108C/T polymorphism and myocardial infarction in the Tunisian male population / Tunuslu erkek populasyonunda miyokard enfarktüs ile paraoksonaz -1 gen başlatıcı -108C/T polimorfizmi arasındaki ilişki
| Autor: | Riadh Jemaa, Yousra Sediri, Amani Kallel, Mohamed Sami Mourali, Moncef Feki, Mohamed Hédi Sbaï, Mehdi Ben Lassoued, Naziha Kaabachi |
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| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Turkish Journal of Biochemistry. 41 |
| ISSN: | 1303-829X 0250-4685 |
| DOI: | 10.1515/tjb-2016-0012 |
| Popis: | Objective: Human paraoxonase 1 (PON1) is an HDL-associated enzyme with anti-oxidant/anti-inflammatory properties that has been suggested to play an important protective role against coronary artery disease (CAD). The PON1 promoter -108C/T polymorphism has been analyzed in numerous association studies as a genetic marker for CAD, however, with controversial results. The aim of this study was to evaluate the association of PON-1 promoter -108C/T polymorphism with the risk of myocardial infarction (MI) in the Tunisian male population.Methods: A total of 815 subjects were recruited, including 318 healthy controls and 497 MI patients. Genotypes were determined by PCR-RFLP method. Genotype/allele frequencies were compared in patients and controls using the chi-square test.Results: Genotype distributions and allele frequencies of PON-1 promoter -108C/T polymorphism were different among the control and MI groups. Patients with MI had significantly higher frequency of the TT genotype compared to controls [29.2% vs. 25.5%; OR (95% CI), 1.67 (1.52-2.49); p=0.010]. The MI patient group showed a significant higher frequency of the T allele compared to the controls [0.56 vs. 0.51; χConclusion: The present study showed a significant and independent association between the PON-1 promoter -108C/T polymorphism and MI in the Tunisian male population. |
| Databáze: | OpenAIRE |
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