Abstract WP62: Favorable Clot Characteristics Predict Smaller Infarct Volume in Acute Ischemic Stroke Patients Treated With Reperfusion Therapy
| Autor: | Bijoy K Menon, MacKenzie Horn, Negar Asdaghi, Talip Asil, Abdulaziz S Al Sultan, Dar Dowlatshahi, Robert Mikulik, Mohammed Najm, Andrew M. Demchuk, Seong Hwan Ahn, Mayank Goyal, Colin Casault, Michael D. Hill, Sung-II Sohn, Josep Puig, Ana Calleja, Mar Castellanos, Jean-Martin Boulanger, Thalia S. Field, Anneliese Neweduk, A.Y. Poppe, Fahad S. Al-Ajlan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty medicine.diagnostic_test business.industry Computed tomography medicine.disease Infarct size Reperfusion therapy Internal medicine Angiography Infarct volume medicine Cardiology Neurology (clinical) Cardiology and Cardiovascular Medicine Prospective cohort study business Acute ischemic stroke Stroke |
| Zdroj: | Stroke. 49 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/str.49.suppl_1.wp62 |
| Popis: | Introduction: Multiple studies have correlated larger final infarct volume (FIV) with worse clinical outcomes. In INTERRSeCT , an international multicenter prospective cohort study, we sought to determine the favorable intracranial clot characteristics predicting smaller infarct volumes. Methods: FIV was measured (24 ±12 hours after baseline imaging) in 605 patients from INTERRSeCT study by blinded readers using Quantomo (Cybertrial Inc, Calgary). Clot Burden Score (CBS) is a 10-point scale with 10 referring to a completely patent ipsilateral anterior circulation from ICA to both M2 arteries, whereas 0 refers to a completely occluded ipsilateral anterior circulation. Residual Flow Grade (RFG) assesses the radiological permeability of the clot to contrast, with grade 0, 1, and 2 defined as no contrast, diffuse ghosting, and hairline lumen, respectively. Both of these scores were assessed by a blinded reader to the FIV. Using ordinal logistic regression, FIV was divided into deciles as the outcome. CBS and RFG were analyzed from 0 to 10, and 0 to 2, respectively. Two models were used, the first has no recanalization status, while the second included it. Results: The median FIVs with and without recanalization were 12.34 ml (IQR: 32.3 ml) and 22.15 ml (IQR: 60.12ml), respectively. CBS and RFG were independently predictive of FIV (p-value= Conclusions: Residual flow grade and clot burden score are fast and practical techniques for practitioners treating acute ischemic stroke patients. Favorable RFG and CBS independently, predict lower infarct volumes regardless of whether recanalization achieved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|