Synthesis of multifunctional upconversion NMOFs for targeted antitumor drug delivery and imaging in triple negative breast cancer cells
| Autor: | Dipranjan Laha, Parimal Karmakar, Soumen Chandra, Sumanta Kumar Sahu, Angshuman Ray Chowdhuri |
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| Rok vydání: | 2017 |
| Předmět: |
Chemistry
Stereochemistry General Chemical Engineering Estrogen receptor 02 engineering and technology General Chemistry Receptor-mediated endocytosis 010402 general chemistry 021001 nanoscience & nanotechnology Endocytosis 01 natural sciences Industrial and Manufacturing Engineering 0104 chemical sciences Folate receptor Drug delivery Cancer research medicine Environmental Chemistry Doxorubicin 0210 nano-technology Cytotoxicity Triple-negative breast cancer medicine.drug |
| Zdroj: | Chemical Engineering Journal. 319:200-211 |
| ISSN: | 1385-8947 |
| DOI: | 10.1016/j.cej.2017.03.008 |
| Popis: | Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 lacking triple negative breast cancers (TNBC) are the leading cause of death. The successful transport of chemotherapeutics in TNBC with receptor mediated targeting and image guided treatment is a serious challenge for cancer therapy. In this work, folic acid encapsulated nanoscale metal organic framework (NMOFs) is developed on the surface of upconversion nanoparticles (UCNPs) as a targeted and pH responsive anticancer drug carrier. To construct the assembled core-shell drug delivery system (DDS), NaYF 4 : Yb 3+ , Er 3+ is taken as UCNPs for its outstanding luminescence properties, then a folic acid encapsulated NMOFs based on tetravalent metal Zr (IV) is directly developed on UCNPs [labeled as UCNP@UIO-66(NH 2 )/FA]. Excitingly, UCNP@UIO-66(NH 2 )/FA are nontoxic towards TNBC cells (MDA-MB-468) and normal cell lines (NIH3T3). The anticancer drug doxorubicin (DOX) is encapsulated into UCNP@UIO-66(NH 2 )/FA with high drug loading efficiency (1.42 g DOX per g NMOFs) and shows pH responsive drug release. The DOX loaded UCNP@UIO-66(NH 2 )/FA successfully enters into the MDA-MB-468 cells through a folate receptor mediated endocytosis and exhibits a higher cytotoxicity than normal cells. Flow cytometry and nuclear apoptosis studies suggest the present DDS can be potential applicable in breast cancer therapy to reduce the side effects. |
| Databáze: | OpenAIRE |
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