IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis

Autor:	L R Brunet, F D Finkelman, A W Cheever, M A Kopf, E J Pearce
Rok vydání:	1997
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 159:777-785
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.159.2.777
Popis:	To examine the role of the Th2-type response during schistosomiasis mansoni we compared disease progression in wild type (wt), and Th2-response deficient IL-4(-/-) mice. Whereas wt C57BL/6 mice tolerate infection and develop chronic disease, IL-4(-/-) C57BL/6 animals are highly susceptible, exhibiting severe acute cachexia followed by death. Data point toward morbidity in the IL-4(-/-) C57BL/6 mice being mediated by TNF-alpha, possibly through the uncontrolled production of nitric oxide in target organs such as the ileum. We propose that IL-4 prevents severe disease during schistosomiasis by regulating macrophage activation.
Databáze:	OpenAIRE
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