| Autor: |
W. Hildebrandt, H. Krakowski-Roosen, H. Renk, A. Künkele, R. Sauer, D. Tichy, L. Edler, R. Kinscherf |
| Rok vydání: |
2019 |
| Zdroj: |
Journal of Aging Research and Lifestyle. :1-5 |
| ISSN: |
2534-773X |
| DOI: |
10.14283/jarcp.2019.8 |
| Popis: |
Lowering high plasma levels of homocysteine (tHcy) by folate/vitamin-B-supplementation only unsufficiently protects against cardiovascular diseases and dementia. To enhance therapeutic options, we evaluated whether the significant tHcy-lowering effect of oral N-acetylcysteine (NAC) in sedentary adults (-11.71% [12]) is still detectable on a background of anabolic resistance training (RT) which moderately decreases tHcy itself. Reanalysing a previous randomized controlled double-blinded clinical trial, we compared the effect of oral NAC (8 weeks 1.8 g/d, n=9) to that of placebo (n=8) on postabsorptive tHcy in healthy middle-aged subjects (tHcy 11.82±0.69 µM) undergoing 8 weeks of supervised progressive RT. NAC (+RT) led to a significantly greater reduction of tHcy (-13.97±5.81%) than placebo (+RT) (-3.85±4.81%) as confirmed by ANOVA (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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