Sex and diet, but not exercise, alter cardiovascular ACE2 and TMPRSS2 mRNA levels in aortic banded swine

Autor:	Shannon C. Kelly, Pamela K. Thorne, Emily V. Leary, Craig A. Emter
Rok vydání:	2023
Předmět:	Physiology Physiology (medical)
Zdroj:	Journal of Applied Physiology. 134:482-489
ISSN:	1522-1601 8750-7587
DOI:	10.1152/japplphysiol.00736.2022
Popis:	This retrospective analysis evaluated the impact of exercise, sex, and diet on ACE2 and TMPRSS2 mRNA levels in preclinical swine heart failure models. Unlike normal exercise intensities, exercise training of an intensity tolerable to a patient with heart failure had no influence on ACE2 or TMPRSS2 mRNA. In a tissue-specific manner, ACE2 mRNA levels were altered due to sex and Western diet, whereas TMPRSS2 mRNA levels were sensitive to sex, Western diet, and pig species.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::37f8556a54653c8a6ad4741815d1f3cc https://doi.org/10.1152/japplphysiol.00736.2022 Zobrazit plný text záznamu