Hypothalamic Orexin-Containing Neurons in the Hypothalamus on Exposure to Antigenic and Non-Antigenic Stimuli

Autor: K Z Shainidze, S V Perekrest, N. S. Novikova, Elena A. Korneva
Rok vydání: 2011
Předmět:
Zdroj: Neuroscience and Behavioral Physiology. 41:188-197
ISSN: 1573-899X
0097-0549
DOI: 10.1007/s11055-011-9399-4
Popis: Orexin is a hypothalamic peptide neurotransmitter first described in 1998. Orexinergic neurons are located predominantly in hypothalamic structures and play an important role in regulating a variety of physiological functions. In the present article we review data on the locations of orexin-containing neurons in the brains of Wistar rats and their projections within the hypothalamus and to other CNS structures. The involvement of orexinergic neurons in regulating feeding behavior and sleep/waking cycles is reviewed, as is its involvement in controlling immune system functions. Experimental data providing a comparative analysis of the responses of orexin-containing neurons to antigenic and non-antigenic stimuli are presented, these providing evidence of the functional heterogeneity of hypothalamic orexin-containing neurons, which is particularly apparent in mediating the responses of the brain to antigenic and non-antigenic stimuli. Analysis of both changes in the intensity of the expression of the preproorexin gene and the morphofunctional characteristics of hypothalamic orexin-containing neurons after exposure to antigens provides grounds for their possible involvement in the mechanisms mediating the responses of the brains to antigens.
Databáze: OpenAIRE
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