Searching Genes Encoding Leishmania Antigens for Diagnosis and Protection

Autor: Manuel Soto, Laura Ramírez, Miguel A. Pineda, Victor M. González, Petter F. Entringer, Camila Indiani de Oliveira, Ivan P. Nascimento, Ana P. Souza, Laura Corvo, Carlos Alonso, Pedro Bonay, Claudia Brodskyn, Aldina Barral, Manoel Barral-Netto, Salvador Iborra
Rok vydání: 2009
Předmět:
Zdroj: Scholarly Research Exchange. 2009:1-25
ISSN: 1687-8302
1687-8299
Popis: Leishmaniases are a wide spectrum of parasitic diseases caused by the infection of different species of the genus Leishmania. Currently, these diseases are one of the most neglected diseases threatening 350 million people in different countries around the world. Thus, these diseases require better screening, diagnostics and treatment. An effective vaccine, that is not currently available, would be the best way to confront leishmaniases. In the past 20 years the molecular characterization of Leishmania genes encoding parasite antigens has been carried out. In this review we summarize the most common strategies employed for the isolation and characterization of genes encoding Leishmania antigens. To provide a collective view, we also discuss the results related with diagnosis and protection based on different recombinant DNA-derived Leishmania products.
Databáze: OpenAIRE
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