Lymph node stroma join the cancer support network

Autor:	Anne L. Fletcher, Tracy Heng
Rok vydání:	2016
Předmět:	0301 basic medicine Lymph node stroma Programmed cell death Pathology medicine.medical_specialty Cell growth Cancer Cell Biology Biology medicine.disease 03 medical and health sciences 030104 developmental biology Immune system Antigen medicine Lymph Antigen-presenting cell Molecular Biology
Zdroj:	Cell Death & Differentiation. 23:1899-1901
ISSN:	1476-5403 1350-9047
DOI:	10.1038/cdd.2016.103
Popis:	Lymph nodes (LNs) are sentinels of the immune system. They allow the lymph draining from peripheral tissues to pass through a leucocytic filter, bringing lymph-borne antigens, inflammatory mediators and antigen presenting cells into close proximity with immune cells capable of responding to antigen exposure.1 Although LNs are often the first site of tumour metastasis for many cancers, it remains unclear how tumour development affects LN structure and function, and how these changes in turn drive tumour growth. Riedel et al.2 have now shown that tumour-draining lymph nodes (TDLNs) respond dynamically to tumour-derived signals early in tumour development, with transcriptional, compositional and structural changes that have important implications for tumour growth.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::37ed2ec894c3f8f13f1d5a02c3c9e178 https://doi.org/10.1038/cdd.2016.103 Zobrazit plný text záznamu Full text from SpringerLink